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DOT Physical Exam & Drug Test Requirements for CDL Drivers:

Jul 1, 2025

7 min

If you're pursuing a career in trucking or managing a fleet, staying compliant with Department of Transportation (DOT) regulations is critical. One of the key requirements for commercial drivers is passing the DOT physical, which includes a DOT drug test. This guide breaks down what drivers can expect during the process, and how the right technology can help simplify recruiting and compliance.

What Is a DOT Physical?

A DOT physical exam is a federally mandated health screening required for anyone operating a commercial motor vehicle (CMV) with a gross vehicle weight rating (GVWR) of over 10,000 lbs. This physical exam plays a crucial role in ensuring that drivers are physically, mentally, and emotionally capable of safely operating vehicles in compliance with Department of Transportation (DOT) regulations.

The DOT physical is especially important for individuals applying for or maintaining a commercial driver’s license (CDL). It is also a critical step in the pre-employment drug test process for trucking companies looking to hire qualified and compliant drivers.

What Does the DOT Physical Include?

The physical includes checks for:

  • Vision and hearing

  • Blood pressure and pulse rate

  • Urinalysis (for signs of underlying health conditions)

  • General physical examination (heart, lungs, spine, neurological health)

But one of the most important components for many carriers is the DOT drug test.

What Is the DOT Drug Test?

During the DOT physical exam, a certified medical examiner, listed in the FMCSA National Registry, evaluates a driver's overall health through a combination of tests and a review of their medical history. The exam typically includes:

  • Vision and hearing test: Ensures drivers meet minimum standards for seeing and hearing road conditions and safety signals.

  • Blood pressure and pulse rate: Helps detect risks related to cardiovascular health.

  • Urinalysis: Primarily used to detect signs of underlying medical conditions such as diabetes, which is often linked to blood sugar levels.

  • Neurological and musculoskeletal assessment: Evaluates reflexes, balance, spine alignment, and limb functionality.

  • Review of medical history: The examiner will ask about past surgeries, hospitalizations, medications, and any diagnosed medical conditions.

Depending on the findings, the medical examiner’s discretion can impact whether a driver is granted a valid DOT medical card, which is required to legally operate a CMV. In some cases, the examiner may issue a temporary card or require additional medical documentation for certain conditions (e.g., high blood pressure, diabetes, or sleep apnea).

If a driver is returning to work after a suspension or medical disqualification, the return to duty process may also involve a new DOT physical exam and drug test to confirm fitness for duty.

The DOT medical card is typically valid for up to 24 months but may be issued for shorter periods if there are health concerns that need ongoing monitoring.

Maintaining a valid DOT physical is not just a regulatory requirement, it’s essential for ensuring driver safety, public safety, and job readiness across the commercial driving industry.

When Is a DOT Drug Test Required?

To ensure public safety and compliance with federal regulations, the Department of Transportation (DOT) requires CDL drivers to undergo drug testing under specific circumstances. This process is commonly referred to as a DOT drug screen and is a critical component of the overall qualification process for those who want to operate a commercial vehicle.

DOT drug testing helps determine whether a driver is mentally fit and free from controlled substances or other drugs that may impair their ability to drive safely.

Here are the key situations when a DOT drug test is required:

1. Pre-Employment

Before a driver is allowed to perform any safety-sensitive functions, such as operating a commercial vehicle, they must pass a pre-employment drug screen. A negative result is mandatory to begin work, and it is often required before issuing or validating a DOT medical certificate.

2. Random Testing

CDL drivers are subject to random drug and alcohol testing throughout the year. These unannounced tests ensure ongoing compliance and safety. Carriers are required to test a certain percentage of their workforce annually under federal guidelines.

3. Post-Accident Testing

If a driver is involved in an accident that meets specific DOT criteria (e.g., a fatality or a citation plus injury or vehicle damage), a post-accident drug screen is required. This test must be administered within a limited time window, typically within 32 hours.

4. Reasonable Suspicion Testing

If a supervisor or employer observes behaviors that suggest drug or alcohol use, such as slurred speech, unsteady movement, or erratic behavior, a reasonable suspicion drug and alcohol test may be conducted. These observations must be documented and based on specific training.

5. Return-to-Duty and Follow-Up Testing

Drivers who have violated the DOT's drug and alcohol policy must go through a rigorous return-to-duty process, which includes evaluation by a substance abuse professional (SAP), a DOT drug screen, and a series of unannounced follow-up tests over the next 12 to 60 months.

What About Medications?

Not all substances detected during a DOT drug screen are illegal, but many prescription medications can still disqualify a driver, especially if they impair the ability to drive safely or operate heavy machinery.

Drivers are required to disclose their medications during the DOT physical. The medical examiner, not a primary care physician, will determine whether the driver is mentally fit and physically capable based on the medication’s potential effects. This decision directly affects whether the driver receives or renews their medical certificate.

Medications that may raise red flags include:

  • Narcotic pain medications (opioids)

  • Benzodiazepines (e.g., Xanax, Valium)

  • Amphetamines (unless properly prescribed and disclosed)

  • Medical marijuana (even if legal in the state, it is still disqualifying under federal law)

Drivers should be honest about any medications they’re taking. Failure to disclose them can result in immediate disqualification, loss of a DOT medical certificate, or legal consequences in the event of an accident or audit.

How Long Are Results Valid?

A negative pre-employment DOT drug test is typically valid for 30 days. However, drivers must be part of a random testing pool to remain compliant. Carriers are responsible for maintaining accurate testing records and ensuring drivers stay up-to-date.

Simplify Driver Compliance with Our Truck Driver Recruiting Software

Managing the complexities of DOT compliance, especially drug testing, can be overwhelming. That’s where our truck driver recruiting software comes in.

Our platform helps recruiters and fleet managers:

  • Track DOT physical and drug test statuses

  • Automate reminders for expiring certifications

  • Store and manage driver documents securely

  • Connect with pre-screened, qualified CDL candidates

  • Streamline the hiring process from application to onboarding

Whether you're hiring one driver or hundreds, our software helps you stay compliant, save time, and reduce risk.

Ready to make driver recruiting and DOT compliance easier? Schedule a free demo today or contact our team to learn more.